Cloud computing has undoubtedly changed how enterprise IT is delivered. It has opened the door to compute and storage resources without limits, as well as a wealth of cloud services (e.g., artificial intelligence, weather data, etc.) for IT administrators to leverage and create the next wave of enterprise innovation. This paper provides a practical guide for IBM Power System™ users to gain an understanding of the POWER® cloud portfolio and how to map out a journey to a secure and reliable hybrid multicloud infrastructure.